Associate Scientist/Scientist I/Scientist II – Protein Engineering

About Enlaza Therapeutics

Enlaza Therapeutics is a biotech company developing an innovative synthetic biology platform to create a new and unique class of biological medicines. We are dedicated to the development of these novel therapies to help patients suffering from cancer and other serious diseases.

Role Description

This position is for a Scientist with expertise in protein engineering to help drive our drug discovery programs. We seek an individual that is proficient in designing and executing experiments, has excellent communication and documentation skills, and is excited to expand their skillset in a fast-paced and collaborative research environment. This position will work in our discovery team and will be involved in biotherapeutic identification, characterization, optimization, and selection of lead molecules for multiple programs. This is an excellent opportunity to work with a motivated and experienced team and interface directly with multiple research groups, including platform engineering, protein sciences, pharmacology, and leadership. The ideal candidate will be an enthusiastic, motivated, and innovative individual who is excited to participate in a dedicated team.

Responsibilities

• Design and generate libraries and screen for binding interactions to various protein targets
• Optimize lead antibodies/VHHs by various techniques, including but not limited to affinity maturation, humanization, and liability removal
• Coordinate the characterization of antibodies/VHHs selected from screening, including submitting samples for LCMS, analytical SEC, BLI, cell binding assays, etc., and organizing and presenting the results
• Clearly document results and present at team meetings

Required Skills and Experience

• BS/MS or PhD in Biochemistry, Bioengineering, or related scientific field, with 4+ years of hands-on experience with protein engineering
• Proficiency with PyMOL, MOE, or similar software for protein structure analysis, protein engineering, and library design
• Protein optimization techniques, including but not limited to affinity maturation, humanization, and liability removal
• Highly collaborative with excellent communication skills
• Ability to work effectively in a fast-paced and cross-functional team environment

Additional Experience Preferred but Not Required

• Protein expression and purification from E.coli
• Experience in high-throughput screening techniques
• Proficiency in interpreting data from the following assays: analytical SEC, LCMS, SPR, and BLI

Compensation

In addition to a competitive compensation package with stock options, the company also offers a comprehensive benefits package for our employees and their families, which includes medical, dental, vision, and supplemental disability insurance.

Job Type

Full-time

Annual Salary

$115,000-145,000

Supplemental Pay Types

Bonus pay

Benefits

• 401(k)
• Dental insurance
• Employee assistance program
• Flexible schedule
• Flexible spending account
• Health insurance
• Life insurance
• Paid time off
• Parental leave
• Relocation assistance
• Retirement plan
• Vision insurance