Associate Scientist/Scientist/Sr. Scientist – Upstream Process Development

About Enlaza Therapeutics

Enlaza Therapeutics is a biotech company developing an innovative synthetic biology platform to create a unique class of biological medicines. We are dedicated to the development of treatments for serious disease and delivering these to patients.

Role Description

As a key member of the Upstream Process Development Team, the candidate will play a crucial role in designing and optimizing bioreactor processes to produce protein biologics from E. coli. The role requires a balance of hands-on lab work and mentoring junior team members. The successful candidate will possess deep technical expertise in upstream process development and a collaborative spirit to work effectively across internal teams.

  • Design, plan, and execute on key experiments to further Upstream Process Development of the proprietary Enlaza protein production platform, including assisting in the setup and breakdown of bioreactors.
  • Enhance manufacturing technologies, capabilities, and processes including, optimizing media, physical conditions, feed profiles, and scale-up.
  • Mentor and guide junior team members in experimental protocols, troubleshooting experimental issues, and equipment handling.
  • Generate, manage, evaluate, and maintain critical data with high organizational standards, including the initial vetting of bioreactor run integrity.
  • Improve ELN templates and develop tools for more efficient bioreactor data collection and presentation.
  • Author comprehensive technical reports, tech transfer documents, and SOPs.
  • Prepare and deliver scientific presentations as required.
  • Collaborate closely with cross-functional scientists to meet project goals and produce required proteins.
  • Ensure the maintenance of UPD group inventory, including cell banks, stock solutions, and materials; oversee the troubleshooting of operational processes and equipment issues.
  • BS in Biochemical Engineering, Biological Sciences, or a related field with 5+ years relevant industry experience, or MS with 2+ years relevant industry experience.
  • Extensive experience with manufacturing cell culture process development, primarily with microbial systems.
  • Proven hands-on experience with small-scale bioreactor set-up and operations, along with flasks.
  • Strong laboratory skills, including molecular biology techniques (e.g., western blots).
  • Demonstrated ability to write detailed technical documents such as tech transfer documents, SOPs, and progress reports.
Additional experience and skills not required but preferred
  • Direct experience with E. coli upstream process development for biologics.
  • Proficiency in programming reactor control systems, e.g. DASware and Applikon Lucculus.
  • Experience with Benchling, particularly with Benchling insights or API.
  • Experience with advanced data analysis tools and software, such as Python, or JMP.
  • Familiarity with cGMP and tech transfer to CDMOs.
  • Knowledge of regulatory requirements and quality control processes for biologics production.
  • Experience in project management or leading projects in a biotech or pharmaceutical setting.
  • Strong communication and interpersonal skills for effective cross-functional collaboration.
  • Demonstrated problem-solving skills and innovative thinking.

In addition to a competitive compensation package with stock options, the company also offers a comprehensive benefits package for our employees and their families, which includes medical, dental, vision, and supplemental disability insurance.

Job Type


Annual Salary Range

$120,000.00 – $160,000.00

Supplemental Pay Types

Bonus pay

  • 401(k)
  • Dental insurance
  • Employee assistance program
  • Flexible schedule
  • Flexible spending account
  • Health insurance
  • Health savings account
  • Life insurance
  • Paid time off
  • Parental leave
  • Relocation assistance
  • Retirement plan
  • Vision insurance

Application Form

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