Scientist II/Senior Scientist – Phage Display and Molecular Biology

About Enlaza Therapeutics

Enlaza Therapeutics is a biotech company developing an innovative synthetic biology platform to create a new and unique class of biological medicines. We are dedicated to the development of these novel therapies to help patients suffering from cancer and other serious diseases.

Role Description

This position is for an individual with expertise in phage display and molecular biology techniques to help drive our drug discovery programs. We seek an individual that is proficient in designing and executing experiments, has excellent communication and documentation skills, and is excited to expand their skillset in a fast-paced and collaborative research environment. This position will work directly on the development of biotherapeutics for serious diseases, and will be involved in biotherapeutic identification, characterization, optimization, and selection of lead molecules for multiple programs. This is an excellent opportunity to work with a motivated and experienced team and interface directly with multiple research groups, including biotherapeutic discovery, platform engineering, protein sciences, pharmacology, and leadership. The ideal candidate will be an enthusiastic, motivated, and innovative individual who is excited to participate in a dedicated team.

Responsibilities

• Design and generate naïve antibody/VHH phage display libraries
• Design and generate antibody phage display libraries from immune sources
• Develop and execute selection strategies for phage panning campaigns
• Binder screening for antibody and VHH libraries including ELISA and flow cytometry
• Optimize antibody/VHH biophysical and antigen binding properties using phage display
• Sequence analysis, clustering, and in silico characterization of antibodies/VHHs selected from phage libraries
• Clearly document results and present at team meetings

Required Skills and Experience

• MS/PhD in Biochemistry or related scientific field, with 4+ years of hands-on experience with phage display and molecular biology
• Extensive experience in phage library panning, including panning strategy design and execution, and binder screening
• Experience with cloning and DNA library design and construction, including naïve, immune, and affinity maturation libraries
• Highly collaborative with excellent communication skills
• Ability to work effectively in a fast-paced and cross-functional team environment

Additional Experience Preferred but Not Required

• Proficiency with PyMOL, MOE, or similar software for protein structure analysis, protein engineering, and library design

• Experience with NGS data analysis

• Knowledge of sequence liabilities and developability assessment

• Proficiency in interpreting data from the following assays: flow cytometry, analytical SEC, LCMS, HIC, and BLI

Compensation

In addition to a competitive compensation package with stock options, the company also offers a comprehensive benefits package for our employees and their families, which includes medical, dental, vision, and supplemental disability insurance.

Job Type

Full-time

Annual Salary

$137,000-155,000

Supplemental Pay Types

Bonus pay

Benefits

• 401(k)
• Dental insurance
• Employee assistance program
• Flexible schedule
• Flexible spending account
• Health insurance
• Life insurance
• Paid time off
• Parental leave
• Relocation assistance
• Retirement plan
• Vision insurance