Scientist/Senior Scientist/Principal Scientist, Computation-aided Protein Drug Design

About Enlaza Therapeutics

Enlaza Therapeutics is a biotech company developing an innovative synthetic biology platform to create a new and unique class of biological medicines. We are dedicated to the development of these novel therapies to help patients suffering from cancer and other serious diseases.

Role Description

Enlaza is seeking a Computational Scientist/ Senior Scientist / Principal Scientist to help design and develop first-in-class covalent protein therapeutics. The scientist will rationally design novel protein-based therapeutics integrating structural, chemical and biological data, and using cutting-edge computational methodologies, artificial intelligence and machine learning techniques. This is a full-time position located at our corporate headquarters in San Diego, CA, with flexibility for remote or hybrid work.

  • Develop and implement computational and machine learning approaches to design protein drugs and optimize binding scaffolds
  • Proactively assess potential structural liabilities and propose optimal development options
  • Work with protein engineers and biologists in streamlining an iterative design-compute-build-test-learn workflow
  • Discover sequence/structure-function relationships by leveraging experimental data
  • Work with subject matter experts on cross-functional teams to advance discovery projects from target identification, protein drug design and optimization through to candidate nomination
  • Contribute to ongoing innovation within the company by staying up-to-date on the latest trends in machine learning and computational drug design, and applying these technologies to develop new drug discovery methods

The above description is intended to describe the general nature of the job and may include other duties as assumed or assigned; it is not intended to be all inclusive or limit the duties of the position.

Required Skills and Experience
  • A PhD in structural bioinformatics, computational biology, physics or a related field
  • Hands-on experience with design and modeling of protein drugs and protein-protein interactions using state-of-the-art commercial and open-source molecular modeling tools
  • Prior experience in applying computational modeling in the biopharmaceutical industry is a plus
  • Strong ability to communicate ideas and results in a cross-functional environment
  • Experience in scripting to develop custom computational workflows
  • Ability to leverage experimental data to inform and refine computational approaches
  • Familiarity with cloud computing platforms

In addition to a competitive compensation package with stock options, the Company also offers a comprehensive benefits package for our employees and their families, which includes medical, dental, vision, and supplemental disability insurance.

Job Type


Annual Salary

$120,000.00 – $190,000.00

Application Form

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